It was first isolated in in Tanzania and is an RNA virus with a positive-sense single-stranded genome of about
Washington University in St. Chikungunya is a growing threat to the United States and other regions of the world as the mosquito that carries the virus expands its reach.
Telltale symptoms of chikungunya infection are fever and joint pain that last about a week. But in up to half of patients, the virus can cause a debilitating form of arthritis. The new findings, which appear in the journal Naturecould lead to ways to prevent or treat disease caused by chikungunya and related viruses.
The handle, or receptor, is located on cells that build cartilage, muscle, and bone. Further, by creating decoy handles, the researchers showed that they could reduce chikungunya infection and signs of arthritis.
Louis School of Medicine. If the virus cannot get into the cell, it is unable to replicate and cause infection and disease. There are no specific treatments or vaccines for chikungunya and related viruses, known as arthritogenic alphaviruses.
Doctors simply recommend rest, fluids, and over-the-counter pain relievers such as acetaminophen or ibuprofen. With the aid of a warming planet and modern means of transportation, mosquitoes that carry chikungunya and related viruses are spreading.
Once limited to Asia and Africa, chikungunya virus has infected more than a million people in the Caribbean and South America in an outbreak that began in and continues to this day.
Figuring out how the virus gets inside cells is considered a step toward slowing its spread. Diamond, first author and postdoctoral researcher Rong Zhang, and colleagues identified the protein on cells that chikungunya virus latches onto.
The protein is called Mxra8, and it is needed for chikungunya to invade both human and mouse cells, the researchers found. Since chikungunya uses Mxra8 protein as a handle to open a door into cells, the researchers tested whether preventing the virus from grabbing that handle could reduce infection.
They deluged the virus with decoy handles, reasoning that chikungunya would grab the decoy and be locked out of cells. Only the few individual viruses that lucked onto a true handle could infect cells, so the overall infection rate—and signs of arthritis—would fall.
In addition, three days after treatment, the mice that had received the protein exhibited much less swelling in their ankles than those that received the placebo.
Can 1 vaccine fight Chikungunya and other viruses? The results suggest that a compound that blocks the virus from attaching to Mxra8 on the surface of cells could prevent or reduce arthritis.Chikungunya virus (CHIKV), is a member of the genus Alphavirus, and family tranceformingnlp.com was first isolated in in Tanzania and is an RNA virus with a positive-sense single-stranded genome of about kb.
It is a member of the Semliki Forest virus complex and is closely related to Ross River virus, O'nyong'nyong virus, and Semliki Forest virus. Identifying dengue fever "hot spots" can provide a predictive map for outbreaks of chikungunya and Zika -- two other viral diseases that, along with dengue, are spread by the Aedes aegypti mosquito.
The explosive pandemic of Zika virus infection in South and Central America is the most recent of four unexpected arrivals of important arthropod-borne viral diseases in the Western Hemisphere.
Congenital Zika virus infection can cause microcephaly and severe brain abnormalities (1).Congenital Zika syndrome comprises a spectrum of clinical features (2); however, as is the case with most newly recognized teratogens, the earliest documented clinical presentation is expected to be the most tranceformingnlp.coml descriptions of the effects of in utero Zika virus infection centered prominently.
1. Define the pathogenesis of Chikungunya virus (CHIK-V) and describe the factors which contribute to the processes of virus infection, spread, and disease causation. 2.
Identify the role of domesticated and wild animals in the spread of CHIK-V. 3. Recall the epidemiology of CHIK-V including the distribution and determinants of disease. 4. 4 A case-control study from Rio de Janeiro showed that fetal abnormalities in 12 of 42 Zika-virus-positive pregnant women studied occurred with infections during all three pregnancy trimesters.